S-EPMC8364589 - Imaging angiogenesis in atherosclerosis in large arteries with <sup>68</sup>Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease. - OmicsDI

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Dataset Information

Imaging angiogenesis in atherosclerosis in large arteries with ⁶⁸Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease.

ABSTRACT:

Background

Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The aim of this study was to assess the clinical correlates of arterial wall accumulation of ⁶⁸Ga-NODAGA-RGD, a specific α_vβ₃ integrin ligand for PET.

Materials and methods

The data of 44 patients who underwent ⁶⁸Ga-NODAGA-RGD PET/CT scans were retrospectively analyzed. Tracer accumulation in the vessel wall of major arteries was analyzed semi-quantitatively by blood-pool-corrected target-to-background ratios. Tracer uptake was compared with clinically documented atherosclerotic cardiovascular disease, cardiovascular risk factors and calcified plaque burden. Data were compared using the Mann-Whitney U test, Pearson correlation and Spearman correlation.

Results

⁶⁸Ga-NODAGA-RGD arterial uptake was significantly higher in patients with previous clinically documented atherosclerotic cardiovascular disease (mean TBR 2.44 [2.03-2.55] vs. 1.81 [1.56-1.96], p = 0.001) and showed a significant correlation with prior cardiovascular or cerebrovascular event (r = 0.33, p = 0.027), BMI (ρ = 0.38, p = 0.01), plaque burden (ρ = 0.31, p = 0.04) and hypercholesterolemia (r = 0.31, p = 0.04).

Conclusions

⁶⁸Ga-NODAGA-RGD holds promise as a non-invasive marker of disease activity in atherosclerosis, providing information about intraplaque angiogenesis.

SUBMITTER: Dietz M

PROVIDER: S-EPMC8364589 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Publications

Imaging angiogenesis in atherosclerosis in large arteries with <sup>68</sup>Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease.

Dietz Matthieu M Kamani Christel H CH Deshayes Emmanuel E Dunet Vincent V Mitsakis Periklis P Coukos George G Nicod Lalonde Marie M Schaefer Niklaus N Prior John O JO

EJNMMI research 20210814 1

<h4>Background</h4>Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The aim of this study was to assess the clinical correlates of arterial wall accumulation of <sup>68</sup>Ga-NODAGA-RGD, a specific α<sub>v</sub>β<sub>3</sub> integrin ligand for PET.<h4>Materials and methods</h4>The data of 44 patients who underwent <sup>68</sup>Ga-NODAGA-RGD ...[more]

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