Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study.

ABSTRACT:

Background

Preliminary studies have suggested that the renin-angiotensin system is activated in critical illness and associated with mortality and kidney outcomes. We sought to assess in a larger, multicenter study the relationship between serum renin and Major Adverse Kidney Events (MAKE) in intensive care unit (ICU) patients.

Methods

Prospective, multicenter study at two institutions of patients with and without acute kidney injury (AKI). Blood samples were collected for renin measurement a median of 2 days into the index ICU admission and 5-7 days later. The primary outcome was MAKE at hospital discharge, a composite of mortality, kidney replacement therapy, or reduced estimated glomerular filtration rate to ≤ 75% of baseline.

Results

Patients in the highest renin

SUBMITTER: Flannery AH 

PROVIDER: S-EPMC8364694 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature