Sensitization to the prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA).

ABSTRACT: The recreational drug 3,4-methylenedioxymethamphetamine (MDMA) has well documented prosocial effects and is currently under clinical investigation as a treatment for patients with PTSD, autism, and other conditions. Early clinical trials have found that MDMA-assisted therapy may have robust long-lasting therapeutic effects, yet the mechanism by which acute treatments produce these long-term effects is unclear. Sensitization to certain behavioral drug effects is a common rodent model used to assess long-lasting neurobiological adaptations induced by acute drug treatments. Nine independent experiments were undertaken to investigate if and how mice sensitize to the prosocial effects of MDMA. When treated with 7.8 mg/kg MDMA and paired every other day for a week, MDMA-induced social interactio

SUBMITTER: Curry DW 

PROVIDER: S-EPMC8364737 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature