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Olfactory Stimulation Modulates Visual Perception Without Training.

ABSTRACT: Considerable research shows that olfactory stimulations affect other modalities in high-level cognitive functions such as emotion. However, little known fact is that olfaction modulates low-level perception of other sensory modalities. Although some studies showed that olfaction had influenced on the other low-level perception, all of them required specific experiences like perceptual training. To test the possibility that olfaction modulates low-level perception without training, we conducted a series of psychophysical and neuroimaging experiments. From the results of a visual task in which participants reported the speed of moving dots, we found that participants perceived the slower motions with a lemon smell and the faster motions with a vanilla smell, without any specific training. In functional magnetic resonance imaging (fMRI) studies, brain activities in the visual cortices [V1 and human middle temporal area (hMT)] changed based on the type of olfactory stimulation. Our findings provide us with the first direct evidence that olfaction modulates low-level visual perception without training, thereby indicating that olfactory-visual effect is not an acquired behavior but an innate behavior. The present results show us with a new crossmodal effect between olfaction and vision, and bring a unique opportunity to reconsider some fundamental roles of olfactory function.

SUBMITTER: Tsushima Y

PROVIDER: S-EPMC8364961 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Median nerve stimulation (MNS) had been performed in the existing literature to alleviate symptoms of nausea and vomiting. The observed facilitative effects are thought to be mediated by the vagal pathways, particularly the vagus nerve (VN) brainstem nuclei of the dorsal motor nucleus of vagus and nucleus tractus solitarius (DMV-NTS). Sense of smell is one of the major sensory modalities for inducing vomiting and nausea as a primary defense against potentially harmful intake of material. This study aimed to test effects of non-invasive, high and low frequency MNS on human olfactory functioning, with supplementary exploration of the orbitofrontal cortex (OFC) using near-infrared spectroscopy (NIRS). Twenty healthy, male, adults performed supra-threshold odor intensity tests (labeled magnitude scale, LMS) for four food-related odorant samples (presented in three different concentrations) before and after receiving high-, low frequency MNS and placebo (no stimulation), while cortical activities in the OFC was monitored by the NIRS. Data of the NIRS and LMS test of separate stimulation parameters were statistically analyzed using mixed-model analysis of variance (ANOVA). Only the high frequency MNS showed effects for suppressing the intensity perception of the moderate concentration of Amyl Acetate (p:0.042) and strong concentration of Isovaleric Acid (p:0.004) and 1-Octen-3-ol (p:0.006). These behavioral changes were coupled with significant changes in the NIRS recordings of the left (p:0.000) and right (p:0.003) hemispheric orbitofrontal cortices. This is the first study that applied non-invasive, high frequency MNS to suppress the supra-threshold odor ratings of specific concentrations of odors. The vagal networks are potential relays of MNS to influence OFC. Results from the current article implore further research into non-invasive, high frequency MNS in the investigation of its modulatory effects on olfactory function, given its potential to be used for ameliorating nausea and malnutrition associated with various health conditions.

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Olfactory Stimulation Modulates Visual Perception Without Training.

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