Ontology highlight
ABSTRACT:
SUBMITTER: Jing Y
PROVIDER: S-EPMC8365108 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Jing Yanyan Y Ren Yonggang Y Witzel Hagen Roland HR Dobreva Gergana G
Stem cell reports 20210729 8
During development, cells respond rapidly to intra- and intercellular signals, which induce signaling cascades regulating the activity of transcription factors at the transcriptional and/or post-translational level. The transcription factor ISL1 plays a key role in second heart field development and cardiac differentiation, and its mRNA levels are tightly regulated during cardiogenesis. Here, we show that a BMP-p38 MAPK signaling axis controls ISL1 protein function at the post-translational leve ...[more]