Novel miR-5088-5p promotes malignancy of breast cancer by inhibiting DBC2.

ABSTRACT: Breast cancer is the most common female cancer in the world. Despite the active research on metastatic breast cancer, the treatment of breast cancer patients is still difficult because the mechanism is not well known. Therefore, research on new targets and mechanisms for diagnosis and treatment of breast cancer patients is required. On the other hand, microRNA (miRNA) has the advantage of simultaneously regulating the expression of many target genes, so it has been proposed as an effective biomarker for the treatment of various diseases including cancer. This study analyzed the role and mechanism of DBC2 (deleted in breast cancer 2), which is known to inhibit its expression in breast cancer, and proposed microRNA (miR)-5088-5p, which regulates its expression. It was revealed that the bioge

SUBMITTER: Seok HJ 

PROVIDER: S-EPMC8365326 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature