Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update.

ABSTRACT:

Background

Uveitis is one of the most frequent ophthalmologic manifestations in rheumatology. Uveal inflammation can underlie a systemic inflammatory rheumatic disease (SIRD) in approximately 30% of cases with a significant burden on the quality of life since it represents a cause of blindness in up to 20% of cases in Western countries.

Methods

In this review, we provide a comprehensive overview of the pathophysiology of uveitis associated with SIRDs. According to our literature survey on the epidemiology of uveitis among SIRDs, spondyloarthritides, Behçet's disease and sarcoidosis get the major impact.

Results

In Behçet's uveitis, the key players are highly polarized Th1 and Th17 lymphocytes, natural killer T cells and γδ T cells. All contribute to a great destructiv

SUBMITTER: Hysa E 

PROVIDER: S-EPMC8365741 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature