Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice.

ABSTRACT:

Background

Given the clinical low efficient treatment based on mono-brain-target design in Alzheimer's disease (AD) and an increasing emphasis on microbiome-gut-brain axis which was considered as a crucial pathway to affect the progress of AD along with metabolic changes, integrative metabolomic signatures and microbiotic community profilings were applied on the early age (2-month) and mature age (6-month) of presenilin1/2 conditional double knockout (PS cDKO) mice which exhibit a series of AD-like phenotypes, comparing with gender and age-matched C57BL/6 wild-type (WT) mice to clarify the relationship between microbiota and metabolomic changes during the disease progression of AD.

Materials and methods

Urinary and fecal samples from PS cDKO mice and gender-matched C57BL/6 w

SUBMITTER: Gao J 

PROVIDER: S-EPMC8365912 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature