Ontology highlight
ABSTRACT:
SUBMITTER: Knochelmann HM
PROVIDER: S-EPMC8366547 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Knochelmann Hannah M HM Rivera-Reyes Amalia M AM Wyatt Megan M MM Smith Aubrey S AS Chamness Reilley R Dwyer Connor J CJ Bobian Michael M Rangel Rivera Guillermo O GO Horton Joshuva D JD Lilly Michael M Romeo Martin J MJ Timmers Cynthia D CD Rubinstein Mark P MP Neskey David M DM Paulos Chrystal M CM
Oncoimmunology 20210812 1
Adoptive transfer of tumor-infiltrating lymphocytes (TIL) elicits the regression of metastatic malignancies, yet a low proportion of patients achieve complete durable responses. The high incidence of relapse in these patients highlights the need to better understand mechanisms of tumor escape from T cell control. While melanoma has provided the foundation for developing TIL therapy, much less is known about TIL efficacy and relapse in other malignancies. We sought to investigate TIL characterist ...[more]