Targeting ROS/NF-κB sigaling pathway by the seedless black Vitis vinifera polyphenols in CCl₄-intoxicated kidney, lung, brain, and spleen in rats.

ABSTRACT: Carbon tetrachloride (CCl₄) is an abundant environmental pollutant that can generate free radicals and induce oxidative stress in different human and animal organs like the kidney, lung, brain, and spleen, causing toxicity. The present study evaluated the alleviative mechanism of the isolated polyphenolic fraction from seedless (pulp and skin) black Vitis vinifera (VVPF) on systemic oxidative and necroinflammatory stress in CCl₄-intoxicated rats. Here, we found that the administration of VVPF to CCl₄-intoxicated rats for ten days was obviously ameliorated the CCl₄-induced systemic elevation in ROS, NO and TBARS levels, as well as MPO activity. Also, it upregulated the cellular activities of the enzymatic (SOD, and GPx) and non-enzymatic (TAC and

SUBMITTER: Habashy NH 

PROVIDER: S-EPMC8367948 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature