Metabolic Alterations in Preneoplastic Development Revealed by Untargeted Metabolomic Analysis.

ABSTRACT: Metabolic rewiring is a critical hallmark of tumorigenesis and is essential for the development of cancer. Although many key features of metabolic alteration that are crucial for tumor cell survival, proliferation and progression have been identified, these are obtained from studies with established tumors and cancer cell lines. However, information on the essential metabolic changes that occur during pre-neoplastic cell (PNC) development that enables its progression to full blown tumor is still lacking. Here, we present an untargeted metabolomics analysis of human oncogene HRAS^G12V induced PNC development, using a transgenic inducible zebrafish larval skin development model. By comparison with normal sibling controls, we identified six metabolic pathways that are significantly

SUBMITTER: Myllymaki H 

PROVIDER: S-EPMC8369915 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature