Unknown

Dataset Information

0

In Vitro Antibacterial Activity of Cefiderocol against Multidrug-Resistant Acinetobacter baumannii.


ABSTRACT: Cefiderocol (CFDC), a novel siderophore cephalosporin, demonstrates strong activity against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated CFDC alone and in combination with other Gram-negative antibiotics against MDR A. baumannii isolates. Susceptibility testing revealed lower CFDC MIC values (87% of MICs ≤ 4mg/liter) than the comparator Gram-negative agents. Six isolates, with elevated CFDC MICs (16 to 32 mg/liter) were selected for further experiments. Time-kill analyses presented with synergistic activity and beta-lactamase inhibitors increased CFDC susceptibility in each of the isolates.

SUBMITTER: Abdul-Mutakabbir JC 

PROVIDER: S-EPMC8370208 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

<i>In Vitro</i> Antibacterial Activity of Cefiderocol against Multidrug-Resistant Acinetobacter baumannii.

Abdul-Mutakabbir Jacinda C JC   Nguyen Logan L   Maassen Philip T PT   Stamper Kyle C KC   Kebriaei Razieh R   Kaye Keith S KS   Castanheira Mariana M   Rybak Michael J MJ  

Antimicrobial agents and chemotherapy 20210817 9


Cefiderocol (CFDC), a novel siderophore cephalosporin, demonstrates strong activity against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated CFDC alone and in combination with other Gram-negative antibiotics against MDR A. baumannii isolates. Susceptibility testing revealed lower CFDC MIC values (87% of MICs ≤ 4mg/liter) than the comparator Gram-negative agents. Six isolates, with elevated CFDC MICs (16 to 32 mg/liter) were selected for further experiments. Time-  ...[more]

Similar Datasets

| S-EPMC11910616 | biostudies-literature
| S-EPMC10376869 | biostudies-literature
| S-EPMC2693502 | biostudies-literature
| S-EPMC6419615 | biostudies-literature
| S-EPMC7581519 | biostudies-literature
| S-EPMC4649178 | biostudies-literature
| S-EPMC9494975 | biostudies-literature
| S-EPMC6328479 | biostudies-literature
| S-EPMC3486561 | biostudies-literature
| S-EPMC3792912 | biostudies-literature