Ontology highlight
ABSTRACT:
SUBMITTER: Abdul-Mutakabbir JC
PROVIDER: S-EPMC8370208 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Abdul-Mutakabbir Jacinda C JC Nguyen Logan L Maassen Philip T PT Stamper Kyle C KC Kebriaei Razieh R Kaye Keith S KS Castanheira Mariana M Rybak Michael J MJ
Antimicrobial agents and chemotherapy 20210817 9
Cefiderocol (CFDC), a novel siderophore cephalosporin, demonstrates strong activity against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated CFDC alone and in combination with other Gram-negative antibiotics against MDR A. baumannii isolates. Susceptibility testing revealed lower CFDC MIC values (87% of MICs ≤ 4mg/liter) than the comparator Gram-negative agents. Six isolates, with elevated CFDC MICs (16 to 32 mg/liter) were selected for further experiments. Time- ...[more]