Dataset Information

Multidrug-Resistant Klebsiella pneumoniae Clones from Wild Chimpanzees and Termites in Senegal.

ABSTRACT: Antibiotic resistance genes exist naturally in various environments far from human usage. Here, we investigated multidrug-resistant Klebsiella pneumoniae, a common pathogen of chimpanzees and humans. We screened antibiotic-resistant K. pneumoniae from 48 chimpanzee stools and 38 termite mounds (n = 415 samples) collected in protected areas in Senegal. The microsatellite method was used to identify chimpanzee individuals (n = 13). Whole-genome sequencing was performed on K. pneumoniae complex isolates to identify antibiotic-resistant genes and characterize clones. We found a high prevalence of carbapenem-resistant K. pneumoniae among chimpanzee isolates (18/48 samples from 7/13 individuals) and ceftriaxone resistance among both chimpanzee individuals (19/48) and termite mounds (7/415 termites and 3/38 termite mounds). The bla_OXA-48 and the bla_KPC-2 genes were carried by international pOXA-48 and pKPC-2 plasmids, respectively. The ESBL plasmid carried bla_CTX-M-15, bla_TEM-1B, and bla_OXA-1 genes. Genome sequencing of 56 isolates identified two major clones associated with hospital-acquired infections of K. pneumoniae (ST307 and ST147) in chimpanzees and termites, suggesting circulation of strains between the two species, as chimpanzees feed on termites. The source and selection pressure of these clones in this environment need to be explored.

SUBMITTER: Baron SA

PROVIDER: S-EPMC8370229 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Multidrug-Resistant Klebsiella pneumoniae Clones from Wild Chimpanzees and Termites in Senegal.

Baron Sophie Alexandra SA Mediannikov Oleg O Abdallah Rim R Kuete Yimagou Edmond E Medkour Hacène H Dubourg Gregory G Elamire Youssouf Y Afouda Pamela P Ngom Issa Isaac II Angelakis Emmanouil E Davoust Bernard B Diatta Georges G Barciela Amanda A Hernandez-Aguilar R Adriana RA Sokhna Cheikh C Caputo Aurelia A Levasseur Anthony A Rolain Jean-Marc JM Raoult Didier D

Antimicrobial agents and chemotherapy 20210817 9

Antibiotic resistance genes exist naturally in various environments far from human usage. Here, we investigated multidrug-resistant Klebsiella pneumoniae, a common pathogen of chimpanzees and humans. We screened antibiotic-resistant K. pneumoniae from 48 chimpanzee stools and 38 termite mounds (<i>n</i> = 415 samples) collected in protected areas in Senegal. The microsatellite method was used to identify chimpanzee individuals (<i>n</i> = 13). Whole-genome sequencing was performed on K. pneumoni ...[more]

PMID: 34152818

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Dataset Information

Multidrug-Resistant Klebsiella pneumoniae Clones from Wild Chimpanzees and Termites in Senegal.

Publications

Multidrug-Resistant Klebsiella pneumoniae Clones from Wild Chimpanzees and Termites in Senegal.

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