A Role for Monosaccharides in Nucleation Inhibition and Transport of Collagen.

ABSTRACT: Background: Collagenous tissues are composed of precisely oriented, tightly packed collagen fibril bundles to confer the maximal strength within the smallest volume. While this compact form benefits mobility, it consequentially restricts vascularity and cell density to a minimally viable level in some regions. These tissues reside in a homeostatic state with an unstable equilibrium, where perturbations to structure or molecular milieu cause descension into a long-term compromised state. Several studies have shown that glycosaminoglycans are key molecules required for healthy tissue maintenance. Our long-term goal is to determine if glycosaminoglycans serve a critical function of stabilizing soluble monomeric collagen in the interstitial fluid that bathes tissue for immediate

SUBMITTER: Martin CL 

PROVIDER: S-EPMC8370311 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature