The structure of a virus-encoded nucleosome.
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ABSTRACT: Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.
SUBMITTER: Valencia-Sanchez MI
PROVIDER: S-EPMC8370576 | biostudies-literature |
REPOSITORIES: biostudies-literature
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