The structure of a virus-encoded nucleosome.
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ABSTRACT:
SUBMITTER: Valencia-Sanchez MI
PROVIDER: S-EPMC8370576 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
The structure of a virus-encoded nucleosome.
Valencia-Sánchez Marco Igor MI Abini-Agbomson Stephen S Wang Miao M Lee Rachel R Vasilyev Nikita N Zhang Jenny J De Ioannes Pablo P La Scola Bernard B Talbert Paul P Henikoff Steve S Nudler Evgeny E Erives Albert A Armache Karim-Jean KJ
Nature structural & molecular biology 20210429 5
Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes. ...[more]
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