Tripterygium wilfordii derivative LLDT-8 targets CD2 in the treatment of rheumatoid arthritis.

ABSTRACT: Rheumatoid arthritis (RA), a chronic inflammatory synovitis systemic disease, can lead to joint deformities, loss of function and even death. The pathogenesis of RA may be related to genetics, infection and/or sex hormones; however, detailed accounts of the molecular mechanisms underlying its pathogenesis are lacking. In the present study, the synovial tissues of patients with RA and healthy individuals were analyzed to identify the pathogenic signaling pathways and key candidate genes involved in RA. Gene Ontology (GO), pathway enrichment and protein-protein interaction analysis were further used to identify the differentially expressed genes (DEGs) and their potential roles in RA. Molecular docking was used to screen the potential candidate drugs for management of RA. Small interfering R

SUBMITTER: Li Y 

PROVIDER: S-EPMC8372124 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature