ANANSE: an enhancer network-based computational approach for predicting key transcription factors in cell fate determination.

ABSTRACT: Proper cell fate determination is largely orchestrated by complex gene regulatory networks centered around transcription factors. However, experimental elucidation of key transcription factors that drive cellular identity is currently often intractable. Here, we present ANANSE (ANalysis Algorithm for Networks Specified by Enhancers), a network-based method that exploits enhancer-encoded regulatory information to identify the key transcription factors in cell fate determination. As cell type-specific transcription factors predominantly bind to enhancers, we use regulatory networks based on enhancer properties to prioritize transcription factors. First, we predict genome-wide binding profiles of transcription factors in various cell types using enhancer activity and transcription factor bind

SUBMITTER: Xu Q 

PROVIDER: S-EPMC8373078 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature