MiR-92a promotes cervical cancer cell proliferation, invasion, and migration by directly targeting PIK3R1.

ABSTRACT:

Objective

To clarify the role of miR-92a in regulating the malignant progression of cervical cancer and its specific molecular mechanism.

Methods

qRT-PCR was used to detect the differential expression of miR-92a in cervical cancer and adjacent tissues. The effects of overexpression of miR-92a on the proliferation, migration, and invasion of HeLa and SiHa cells were tested. Luciferase assays and rescue experiments were used to investigate the regulatory mechanism of miR-92a on its downstream gene PIK3R1 and their interaction in the progression of cervical cancer.

Results

miR-92a was significantly up-regulated in cervical cancer tissues. Overexpression of miR-92a significantly increased the ability of cervical cancer cells to proliferate, migrate, and invade. PIK3R1 was

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8373326 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature