Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.

ABSTRACT:

Aim

A recent meta-analysis of genome-wide linkage studies (GWLS) has identified multiple genetic regions suggestive of linkage with DN harboring hundreds of genes. Moving this number of genetic loci forward into biological insight is truly the next step. Here, we approach this challenge with a gene ontology (GO) analysis in order to yield biological and functional role to the genes, an over-representation test to find which GO terms are enriched in the gene list, pathway analysis, as well as protein network analysis.

Method

GO analysis was performed using protein analysis through evolutionary relationships (PANTHER) version 14.0 software and P-values less than 0.05 were considered statistically significant. GO analysis was followed by over-representation test for the identif

SUBMITTER: Tziastoudi M 

PROVIDER: S-EPMC8375992 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature