Multiscale model of hepatitis C virus dynamics in plasma and liver following combination therapy.

ABSTRACT: This work explores the application of a physiologically structured population (PSP) framework in modeling hepatitis C virus (HCV) kinetics. To do so, a model was developed for the viral RNA load in plasma and liver as observed in 15 patients treated with a combination therapy of pegylated interferon, ribavirin, and telaprevir. By including both intracellular and extracellular processes of the HCV lifecycle, the model provided a description of the treatment effect on the intracellular HCV lifecycle. Combining PSP models with a nonlinear mixed effects approach in a single model permits a natural inclusion of the direct-acting antiviral effect on intracellular processes, which can then be integrated with the viral kinetics within the host while accounting for the interindividual variability b

SUBMITTER: Woot de Trixhe X 

PROVIDER: S-EPMC8376145 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature