Genetics of PlGF plasma levels highlights a role of its receptors and supports the link between angiogenesis and immunity.

ABSTRACT: Placental growth factor (PlGF) is a member of the vascular endothelial growth factor family and is involved in bone marrow-derived cell activation, endothelial stimulation and pathological angiogenesis. High levels of PlGF have been observed in several pathological conditions especially in cancer, cardiovascular, autoimmune and inflammatory diseases. Little is known about the genetics of circulating PlGF levels. Indeed, although the heritability of circulating PlGF levels is around 40%, no studies have assessed the relation between PlGF plasma levels and genetic variants at a genome-wide level. In the current study, PlGF plasma levels were measured in a population-based sample of 2085 adult individuals from three isolated populations of South Italy. A GWAS was performed in a discovery coho

SUBMITTER: Ruggiero D 

PROVIDER: S-EPMC8376970 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature