Unknown

Dataset Information

0

From CAR-T Cells to CAR-NK Cells: A Developing Immunotherapy Method for Hematological Malignancies.


ABSTRACT: The approval of CD19 chimeric antigen receptor (CAR)-engineered T (CAR-T) cell products in B-cell malignancies represents a breakthrough in CAR-T cell immunotherapy. However, the remaining limitations concerning the graft-versus-host disease (GVHD) and other adverse effects (e.g., cytokine release syndromes [CRS] and neurotoxicity) still restrict their wider applications. Natural killer (NK) cells have been identified as promising candidates for CAR-based cellular immunotherapy because of their unique characteristics. No HLA-matching restriction and abundant sources make CAR-engineered NK (CAR-NK) cells potentially available to be off-the-shelf products that could be readily available for immediate clinical use. Therefore, researchers have gradually shifted their focus from CAR-T cells to CAR-NK cells in hematological malignancies. This review discusses the current status and applications of CAR-NK cells in hematological malignancies, as well as the unique advantages of CAR-NK cells compared with CAR-T cells. It also discusses challenges and prospects regarding clinical applications of CAR-NK cells.

SUBMITTER: Lu H 

PROVIDER: S-EPMC8377427 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6832127 | biostudies-literature
| S-EPMC8252313 | biostudies-literature
| S-EPMC6709701 | biostudies-literature
| S-EPMC8582420 | biostudies-literature
| S-EPMC8396650 | biostudies-literature
| S-EPMC3689050 | biostudies-literature
| S-EPMC7452675 | biostudies-literature
| S-EPMC5762550 | biostudies-literature
| S-EPMC7738987 | biostudies-literature
| S-EPMC7226455 | biostudies-literature