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Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter.

ABSTRACT: Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die P _y correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die P _y is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner.

SUBMITTER: Vreeman G

PROVIDER: S-EPMC8379284 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter.

Vreeman Gerrit G Sun Changquan Calvin CC

International journal of pharmaceutics: X 20210814

Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die P y correlates strongly with three established plasticity parameters obtained from the out-of- ...[more]

PMID: 34458719

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Dataset Information

Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter.

Publications

Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter.

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