Ontology highlight
ABSTRACT:
SUBMITTER: de Graaf DM
PROVIDER: S-EPMC8380748 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
de Graaf Dennis M DM Teufel Lisa U LU van de Veerdonk Frank L FL Joosten Leo A B LAB Netea Mihai G MG Dinarello Charles A CA Arts Rob J W RJW
Journal of leukocyte biology 20210223 5
Trained immunity is the acquisition of a hyperresponsive phenotype by innate immune cells (such as monocytes and macrophages) after an infection or vaccination, a de facto nonspecific memory dependent on epigenetic and metabolic reprogramming of these cells. We have recently shown that induction of trained immunity is dependent on IL-1β. Here, we show that recombinant IL-38, an anti-inflammatory cytokine of the IL-1-family, was able to induce long-term inhibitory changes and reduce the induction ...[more]