Unknown

Dataset Information

0

Enantioenriched α-substituted glutamates/pyroglutamates via enantioselective cyclopropenimine-catalyzed Michael addition of amino ester imines.


ABSTRACT: A procedure for the enantioselective synthesis of α-substituted glutamates and pyroglutamates via a cyclopropenimine-catalyzed Michael addition of amino ester imines is described. Enantioselectivities of up to 94% have been achieved, and a variety of functional groups were found to be compatible. The impact of the catalyst structure and imine substitution is discussed. Compared to other methods, this protocol allows for a broader and more enantioselective access to pyroglutamate derivatives.

SUBMITTER: Seibel ZM 

PROVIDER: S-EPMC8381810 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3968543 | biostudies-literature
| S-EPMC3804837 | biostudies-literature
| S-EPMC3930154 | biostudies-literature
| S-EPMC5358540 | biostudies-literature
| S-EPMC2819183 | biostudies-literature
| S-EPMC10729023 | biostudies-literature
| S-EPMC9278409 | biostudies-literature
| S-EPMC8793149 | biostudies-literature
| S-EPMC9091971 | biostudies-literature
| S-EPMC3388856 | biostudies-literature