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Photoinduced Skeletal Rearrangement of N-Substituted Colchicine Derivatives.

ABSTRACT: Colchicine is an active pharmaceutical ingredient widely used for treating gout, pericarditis, and familial Mediterranean fever with high antimitotic activity. The photoisomerization of colchicine deactivates its anti-inflammatory and antimitotic properties. However, despite numerous reports on colchicine derivatives, their photostability has not been investigated in detail. This report reveals the effects of UV-induced rearrangement on the structure and reports the biological activity of new N-substituted colchicine derivatives.

SUBMITTER: Czerwonka D

PROVIDER: S-EPMC8383305 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Photoinduced Skeletal Rearrangement of <i>N</i>-Substituted Colchicine Derivatives.

Czerwonka Dominika D Sobczak Szymon S Pędziński Tomasz T Maj Ewa E Wietrzyk Joanna J Celewicz Lech L Katrusiak Andrzej A Huczyński Adam A

The Journal of organic chemistry 20201222 16

Colchicine is an active pharmaceutical ingredient widely used for treating gout, pericarditis, and familial Mediterranean fever with high antimitotic activity. The photoisomerization of colchicine deactivates its anti-inflammatory and antimitotic properties. However, despite numerous reports on colchicine derivatives, their photostability has not been investigated in detail. This report reveals the effects of UV-induced rearrangement on the structure and reports the biological activity of new <i ...[more]

PMID: 33350834

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