Deterministic transition of enterotypes shapes the infant gut microbiome at an early age.

ABSTRACT:

Background

The succession of the gut microbiota during the first few years plays a vital role in human development. We elucidate the characteristics and alternations of the infant gut microbiota to better understand the correlation between infant health and microbiota maturation.

Results

We collect 13,776 fecal samples or datasets from 1956 infants between 1 and 3 years of age, based on multi-population cohorts covering 17 countries. The characteristics of the gut microbiota are analyzed based on enterotype and an ecological model. Clinical information (n = 2287) is integrated to understand outcomes of different developmental patterns. Infants whose gut microbiota are dominated by Firmicutes and Bifidobacterium exhibit typical characteristics of early developmental stages, s

SUBMITTER: Xiao L 

PROVIDER: S-EPMC8383385 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature