Genomic markers associated with successful treatment of hypertension with lisinopril: A pilot study.
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ABSTRACT: Objective
To identify single nucleotide variants (SNVs) associated with lisinopril effectiveness.Materials and methods
This was an observational study using a candidate gene approach to examine SNVs associated with lisinopril effectiveness. Drug effectiveness was defined as 10% decrease in systolic blood pressure at 1 week follow-up. We used the Illumina GWAS MEGA chip to examine variants in the renin/angiotensin pathway that may be associated with drug effectiveness.Results
61 subjects were enrolled, and 33 (54.1%) were responsive to lisinopril therapy. SNVs in AGT (p = 0.0141), REN (p = 0.0192), and ACE2 (p = 0.0002) were found to be associated with successful treatment on lisinopril. Conclusion and relevance: SNVs in the renin and angiotensin pathway are associated with lisinopril effectiveness in a pilot cohort of patients with uncontrolled hypertension.
SUBMITTER: Flaten HK
PROVIDER: S-EPMC8383846 | biostudies-literature |
REPOSITORIES: biostudies-literature
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