Ontology highlight
ABSTRACT:
SUBMITTER: O'Connor MJ
PROVIDER: S-EPMC8384455 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
O'Connor Michael J MJ Thakar Tanay T Nicolae Claudia M CM Moldovan George-Lucian GL
Oncogene 20210622 30
Cyclin D1 is an essential regulator of the G1-S cell-cycle transition and is overexpressed in many cancers. Expression of cyclin D1 is under tight cellular regulation that is controlled by many signaling pathways. Here we report that PARP14, a member of the poly(ADP-ribose) polymerase (PARP) family, is a regulator of cyclin D1 expression. Depletion of PARP14 leads to decreased cyclin D1 protein levels. In cells with a functional retinoblastoma (RB) protein pathway, this results in G1 cell-cycle ...[more]