Ontology highlight
ABSTRACT:
SUBMITTER: Novoyatleva T
PROVIDER: S-EPMC8385080 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Novoyatleva Tatyana T Rai Nabham N Kojonazarov Baktybek B Veeroju Swathi S Ben-Batalla Isabel I Caruso Paola P Shihan Mazen M Presser Nadine N Götz Elsa E Lepper Carina C Herpel Sebastian S Manaud Grégoire G Perros Frédéric F Gall Henning H Ghofrani Hossein Ardeschir HA Weissmann Norbert N Grimminger Friedrich F Wharton John J Wilkins Martin M Upton Paul D PD Loges Sonja S Morrell Nicholas W NW Seeger Werner W Schermuly Ralph T RT
Communications biology 20210824 1
Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e., monocrotaline and Su5416/hypoxia treated rats) and clinical PAH. In vitro Axl inhibition by R428 and Axl knock-down inhibited growth factor-driven proliferation and migration of non-PAH and PAH PASMCs. Conversely, Axl overexpression conferred a growth advantage. Axl declined in PAECs of PAH ...[more]