Review of Mendelian Randomization Studies on Ovarian Cancer.

ABSTRACT: Ovarian cancer (OC) is one of the deadliest gynecological cancers worldwide. Previous observational epidemiological studies have revealed associations between modifiable environmental risk factors and OC risk. However, these studies are prone to confounding, measurement error, and reverse causation, undermining robust causal inference. Mendelian randomization (MR) analysis has been established as a reliable method to investigate the causal relationship between risk factors and diseases using genetic variants to proxy modifiable exposures. Over recent years, MR analysis in OC research has received extensive attention, providing valuable insights into the etiology of OC as well as holding promise for identifying potential therapeutic interventions. This review provides a comprehensive overvi

SUBMITTER: Guo JZ 

PROVIDER: S-EPMC8385140 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature