Smoking induces sex-specific changes in the small airway proteome.

ABSTRACT:

Introduction

Cigarette smoke triggers many cellular and signaling responses in the lung and the resulting inflammation plays a central role in smoke-related lung diseases, such as COPD. We explored the effects of smoking on the small airway proteome in samples obtained by collection of exhaled particles with the aim to identify specific proteins dysregulated by smoking.

Methods

Exhaled particles were obtained from 38 current smokers, 47 former smokers and 22 healthy controls with the PExA method. 120 ng of sample was collected from individual subjects and analyzed with the SOMAscan proteomics platform. General linear model-based statistics were performed.

Results

Two hundred and three proteins were detected in at least half of 107 total samples. Active smoking exerted

SUBMITTER: Kokelj S 

PROVIDER: S-EPMC8385797 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature