The Roles of Alternative Splicing in Tumor-immune Cell Interactions.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC8388066 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
The Roles of Alternative Splicing in Tumor-immune Cell Interactions.
Wang Yue Y Zhang Honglei H Jiao Baowei B Nie Jianyun J Li Xiyin X Wang Wenhuan W Wang Hairui H
Current cancer drug targets 20200101 10
Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and protumoral roles in different types of cancer. For example, ULBP1_RI, MLL5Δ21spe, NKp44-1Δ5, MHC-IΔ7, CD200SΔ1, 2, PVR α/β/γ/δ and IL- ...[more]
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