Self-Assembly of Functionalized Lipophilic Guanosines into Cation-Free Stacked Guanine-Quartets.
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ABSTRACT:
SUBMITTER: Campitiello M
PROVIDER: S-EPMC8389894 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
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Self-Assembly of Functionalized Lipophilic Guanosines into Cation-Free Stacked Guanine-Quartets.
Campitiello Marilena M Cremonini Alessio A Squillaci Marco A MA Pieraccini Silvia S Ciesielski Artur A Samorì Paolo P Masiero Stefano S
The Journal of organic chemistry 20210719 15
The hierarchical self-assembly of various lipophilic guanosines exposing either a phenyl or a ferrocenyl group in the C(8) position was investigated. In a solution, all the derivatives were found to self-assemble primarily into isolated guanine (G)-quartets. In spite of the apparent similar bulkiness of the two substituents, most of the derivatives form disordered structures in the solid state, whereas a specific 8-phenyl derivative self-assembles into an unprecedented, cation-free stacked G-qua ...[more]
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