Ontology highlight
ABSTRACT:
SUBMITTER: Tinto-Font E
PROVIDER: S-EPMC8390444 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Tintó-Font Elisabet E Michel-Todó Lucas L Russell Timothy J TJ Casas-Vila Núria N Conway David J DJ Bozdech Zbynek Z Llinás Manuel M Cortés Alfred A
Nature microbiology 20210816 9
Periodic fever is a characteristic clinical feature of human malaria, but how parasites survive febrile episodes is not known. Although the genomes of Plasmodium species encode a full set of chaperones, they lack the conserved eukaryotic transcription factor HSF1, which activates the expression of chaperones following heat shock. Here, we show that PfAP2-HS, a transcription factor in the ApiAP2 family, regulates the protective heat-shock response in Plasmodium falciparum. PfAP2-HS activates the ...[more]