Dataset Information

Dietary Nutrients and Cardiovascular Risk Factors among Renal Transplant Recipients.

ABSTRACT: Cardiovascular disease (CVD) is the leading cause of mortality in post-renal transplant recipients (RTRs). Adequate nutrient intake is a protective factor for CVD. We examined the associations of macronutrients and micronutrients with traditional and nontraditional CVD risk factors. Conducted from September 2016 to June 2018, this cross-sectional study included 106 RTRs aged ≥18 years with a functioning allograft. Dietary intake data from 3-day dietary records were collected. Nutrient intake adequacy was defined using various instruments, including the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines. CVD risk factors were defined according to the K/DOQI guidelines. Bivariate and multivariate logistic regression models were used to analyze the associations. CVD risk was present in all patients; the lowest proportions of adequate intake were 2.8% for dietary fiber and 0.9% for calcium. Adequate nutrient intake was associated with a lower likelihood of the occurrence of traditional CVD risk factors (specifically, 1.9-31.3% for hyperlipidemia and 94.6% for diabetes mellitus). It was also associated with a lower likelihood of the occurrence of nontraditional CVD risk by 0.8% for hypophosphatemia and 34% for hyperuricemia. Adherence to dietary guidelines should be promoted among RTRs to decrease CVD risk.

SUBMITTER: Lin IH

PROVIDER: S-EPMC8391485 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Dietary Nutrients and Cardiovascular Risk Factors among Renal Transplant Recipients.

Lin I-Hsin IH Duong Tuyen Van TV Wong Te-Chih TC Nien Shih-Wei SW Tseng I-Hsin IH Chiang Yang-Jen YJ Wang Hsu-Han HH Yang Shwu-Huey SH

International journal of environmental research and public health 20210810 16

Cardiovascular disease (CVD) is the leading cause of mortality in post-renal transplant recipients (RTRs). Adequate nutrient intake is a protective factor for CVD. We examined the associations of macronutrients and micronutrients with traditional and nontraditional CVD risk factors. Conducted from September 2016 to June 2018, this cross-sectional study included 106 RTRs aged ≥18 years with a functioning allograft. Dietary intake data from 3-day dietary records were collected. Nutrient intake ade ...[more]

PMID: 34444197

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Project description:ImportanceMelanoma risk factors and incidence in renal transplant recipients can inform decision making for both patients and clinicians.ObjectiveTo determine risk factors and characteristics of renal transplant recipients who develop melanoma.Design, setting, and participantsThis cohort study of a large national data registry used a cohort of renal transplant recipients from the United States Renal Data System (USRDS) database from the years 2004 through 2012. Differences in baseline characteristics between those who did and did not develop melanoma were examined, and a survival analysis was performed. Patients with renal transplants who received a diagnosis of melanoma according to any inpatient or outpatient claim associated with a billing code for melanoma were included. A history of pretransplant melanoma, previous kidney transplantation, or transplantation after 2012 or before 2004 were exclusion criteria. The data analysis was conducted from 2015 to 2016.ExposureReceipt of a renal transplant.Main outcomes and measuresIncidence and risk factors for melanoma.ResultsOf 105?174 patients (64?151 [60.7%] male; mean [SD] age, 49.6 [15.3] years) who received kidney transplants between 2004 and 2012, 488 (0.4%) had a record of melanoma after transplantation. Significant risk factors for developing melanoma vs not developing melanoma included older age among recipients (mean [SD] age, 60.5 [10.2] vs 49.7 [15.3] years; P?<?.001) and donors (42.6 [15.0] vs 39.2 [15.1] years; P?<?.001), male sex (71.5% vs 60.7%; P?<?.001), recipient (96.1% vs 66.5%; P?<?.001) and donor (92.4% vs 82.9%; P?<?.001) white race, less than 4 HLA mismatches (44.9% vs 37.1%; P?=?.001), living donors (44.7% vs 33.7%; P?<?.001), and sirolimus (22.3% vs 13.2%; P?<?.001) and cyclosporine (4.9% vs 3.2%; P?=?.04) therapy. Risk factors significant on survival analysis included older recipient age (hazard ratio [HR] per year, 1.06; 95% CI, 1.05-1.06; P?<?.001), recipient male sex (HR, 1.53; 95% CI, 1.25-1.88; P?<?.001), recipient white race, living donors (HR, 1.35; 95% CI, 1.11-1.64; P?=?.002), and sirolimus (HR, 1.54; 95% CI, 1.22-1.94; P?<?.001) and cyclosporine (HR, 1.93; 95% CI, 1.24-2.99; P = .004) therapy. The age-standardized relative rate of melanoma in USRDS patients compared with Surveillance, Epidemiology, and End Results patients across all years was 4.9. A Kaplan-Meier estimate of the median time to melanoma among those patients who did develop melanoma was 1.45 years (95% CI, 1.31-1.70 years).Conclusions and relevanceRenal transplant recipients had greater risk of developing melanoma than the general population. We believe that the risk factors we identified can guide clinicians in providing adequate care for patients in this vulnerable group.

Dataset Information

Dietary Nutrients and Cardiovascular Risk Factors among Renal Transplant Recipients.

Publications

Dietary Nutrients and Cardiovascular Risk Factors among Renal Transplant Recipients.

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