Ontology highlight
ABSTRACT:
SUBMITTER: Gudas JM
PROVIDER: S-EPMC83919 | biostudies-literature | 1999 Jan
REPOSITORIES: biostudies-literature
Gudas J M JM Payton M M Thukral S S Chen E E Bass M M Robinson M O MO Coats S S
Molecular and cellular biology 19990101 1
A novel cyclin gene was discovered by searching an expressed sequence tag database with a cyclin box profile. The human cyclin E2 gene encodes a 404-amino-acid protein that is most closely related to cyclin E. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27(Kip1) and p21(Cip1). The catalytic activity associated with cyclin E2 complexes is cell cycle regulated and peaks at the G1/S transition. Overexpression of cyclin E2 in mammalian cells accelerates G ...[more]