Salvage Autologous Stem Cell Transplantation in Daratumumab-Refractory Multiple Myeloma.

ABSTRACT: Daratumumab, a CD38-targeting monoclonal antibody, has significantly improved survival rates in multiple myeloma (MM), yet patients who progress on Daratumumab have dismal clinical outcomes with an overall median of less than 10 months. While emerging novel modalities have shown promising results, the current study explores the use of high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) in heavily pretreated Daratumumab-refractory MM patients. We retrospectively investigated the outcome of 69 consecutive patients who received upfront ASCT. The median progression-free survival (PFS) for the entire patient cohort was 7.2 months with a median overall survival (OS) of 19.3 months. For patients with ≥very good partial response (VGPR), median PFS and OS improved to 9 mo

SUBMITTER: Yarlagadda L 

PROVIDER: S-EPMC8392190 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature