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The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer.


ABSTRACT: Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their possible mechanisms of action in prostate cancer. Besides the palliative effects of cannabinoids, research from the past two decades has demonstrated their promising potential as antitumor agents in a wide variety of cancers. This analysis may provide pharmacological insights into the selection of specific cannabinoids for the development of antitumor drugs for the treatment of prostate cancer.

SUBMITTER: Singh K 

PROVIDER: S-EPMC8392233 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer.

Singh Kanika K   Nassar Nazim N   Bachari Ava A   Schanknecht Ellen E   Telukutla Srinivasareddy S   Zomer Roby R   Piva Terrence J TJ   Mantri Nitin N  

Cancers 20210815 16


Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their possible mechanisms of action in prostate cancer. Besides the palliative effects of cannabinoids, research from the past two decades has demonstrated their promising potential as antitumor agents in a w  ...[more]

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