Focusing of Particles in a Microchannel with Laser Engraved Groove Arrays.

ABSTRACT: Continuous microfluidic focusing of particles, both synthetic and biological, is significant for a wide range of applications in industry, biology and biomedicine. In this study, we demonstrate the focusing of particles in a microchannel embedded with glass grooves engraved by femtosecond pulse (fs) laser. Results showed that the laser-engraved microstructures were capable of directing polystyrene particles and mouse myoblast cells (C2C12) towards the center of the microchannel at low Reynolds numbers (Re < 1). Numerical simulation revealed that localized side-to-center secondary flows induced by grooves at the channel bottom play an essential role in particle lateral displacement. Additionally, the focusing performance proved to be dependent on the angle of grooves and the middle open spa

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8392838 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature