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Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer's disease: A tracer kinetic modeling study.


ABSTRACT: [11C]UCB-J PET for synaptic vesicle glycoprotein 2 A (SV2A) has been proposed as a suitable marker for synaptic density in Alzheimer's disease (AD). We compared [11C]UCB-J binding for synaptic density and [18F]FDG uptake for metabolism (correlated with neuronal activity) in 14 AD and 11 cognitively normal (CN) participants. We assessed both absolute and relative outcome measures in brain regions of interest, i.e., K1 or R1 for [11C]UCB-J perfusion, VT (volume of distribution) or DVR to cerebellum for [11C]UCB-J binding to SV2A; and Ki or KiR to cerebellum for [18F]FDG metabolism. [11C]UCB-J binding and [18F]FDG metabolism showed a similar magnitude of reduction in the medial temporal lobe of AD -compared to CN participants. However, the magnitude of reduction of [11C]UCB-J binding in neocortical regions was less than that observed with [18F]FDG metabolism. Inter-tracer correlations were also higher in the medial temporal regions between synaptic density and metabolism, with lower correlations in neocortical regions. [11C]UCB-J perfusion showed a similar pattern to [18F]FDG metabolism, with high inter-tracer regional correlations. In summary, we conducted the first in vivo PET imaging of synaptic density and metabolism in the same AD participants and reported a concordant reduction in medial temporal regions but a discordant reduction in neocortical regions.

SUBMITTER: Chen MK 

PROVIDER: S-EPMC8393289 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Comparison of [<sup>11</sup>C]UCB-J and [<sup>18</sup>F]FDG PET in Alzheimer's disease: A tracer kinetic modeling study.

Chen Ming-Kai MK   Mecca Adam P AP   Naganawa Mika M   Gallezot Jean-Dominique JD   Toyonaga Takuya T   Mondal Jayanta J   Finnema Sjoerd J SJ   Lin Shu-Fei SF   O'Dell Ryan S RS   McDonald Julia W JW   Michalak Hannah R HR   Vander Wyk Brent B   Nabulsi Nabeel B NB   Huang Yiyun Y   Arnsten Amy Ft AF   van Dyck Christopher H CH   Carson Richard E RE  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20210324 9


[<sup>11</sup>C]UCB-J PET for synaptic vesicle glycoprotein 2 A (SV2A) has been proposed as a suitable marker for synaptic density in Alzheimer's disease (AD). We compared [<sup>11</sup>C]UCB-J binding for synaptic density and [<sup>18</sup>F]FDG uptake for metabolism (correlated with neuronal activity) in 14 AD and 11 cognitively normal (CN) participants. We assessed both absolute and relative outcome measures in brain regions of interest, i.e., <i>K</i><sub>1</sub> or <i>R</i><sub>1</sub> for  ...[more]

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