Ontology highlight
ABSTRACT:
SUBMITTER: Chen MK
PROVIDER: S-EPMC8393289 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Chen Ming-Kai MK Mecca Adam P AP Naganawa Mika M Gallezot Jean-Dominique JD Toyonaga Takuya T Mondal Jayanta J Finnema Sjoerd J SJ Lin Shu-Fei SF O'Dell Ryan S RS McDonald Julia W JW Michalak Hannah R HR Vander Wyk Brent B Nabulsi Nabeel B NB Huang Yiyun Y Arnsten Amy Ft AF van Dyck Christopher H CH Carson Richard E RE
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20210324 9
[<sup>11</sup>C]UCB-J PET for synaptic vesicle glycoprotein 2 A (SV2A) has been proposed as a suitable marker for synaptic density in Alzheimer's disease (AD). We compared [<sup>11</sup>C]UCB-J binding for synaptic density and [<sup>18</sup>F]FDG uptake for metabolism (correlated with neuronal activity) in 14 AD and 11 cognitively normal (CN) participants. We assessed both absolute and relative outcome measures in brain regions of interest, i.e., <i>K</i><sub>1</sub> or <i>R</i><sub>1</sub> for ...[more]