I4mC-Deep: An Intelligent Predictor of N4-Methylcytosine Sites Using a Deep Learning Approach with Chemical Properties.

ABSTRACT: DNA is subject to epigenetic modification by the molecule N4-methylcytosine (4mC). N4-methylcytosine plays a crucial role in DNA repair and replication, protects host DNA from degradation, and regulates DNA expression. However, though current experimental techniques can identify 4mC sites, such techniques are expensive and laborious. Therefore, computational tools that can predict 4mC sites would be very useful for understanding the biological mechanism of this vital type of DNA modification. Conventional machine-learning-based methods rely on hand-crafted features, but the new method saves time and computational cost by making use of learned features instead. In this study, we propose i4mC-Deep, an intelligent predictor based on a convolutional neural network (CNN) that predicts 4mC modif

SUBMITTER: Alam W 

PROVIDER: S-EPMC8393747 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature