Adiponectin and Asthma: Knowns, Unknowns and Controversies.

ABSTRACT: Adiponectin is an adipokine associated with the healthy obese phenotype. Adiponectin increases insulin sensitivity and has cardio and vascular protection actions. Studies related to adiponectin, a modulator of the innate and acquired immunity response, have suggested a role of this molecule in asthma. Studies based on various asthma animal models and on the key cells involved in the allergic response have provided important insights about this relation. Some of them indicated protection and others reversed the balance towards negative effects. Many of them described the cellular pathways activated by adiponectin, which are potentially beneficial for asthma prevention or for reduction in the risk of exacerbations. However, conclusive proofs about their efficiency still need to be provided.

SUBMITTER: Otelea MR 

PROVIDER: S-EPMC8396527 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature