Unknown

Dataset Information

0

Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.).


ABSTRACT: Five new thiohydantoin derivatives (1-5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (1H and 13C NMR, 1H-1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds. Significantly, the structure of compound 1 was the first example of thiohydantoins with thioxohexahydroimidazo [1,5-a] pyridine moiety. Additionally, compounds 2 and 3 possess rare disulfide bonds. Except for compound 4, all isolates were assessed for neuroprotective activities in corticosterone (CORT)-stimulated PC12 cell damage. Among them, compound (-)-3 exhibited moderate neuroprotective activity (cell viability: 68.63%, 20 μM) compared to the positive control desipramine (DIM) (cell viability: 88.49%, 10 μM).

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8398295 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7021813 | biostudies-literature
| S-EPMC9740802 | biostudies-literature
| S-EPMC6071217 | biostudies-literature
| S-EPMC6195103 | biostudies-literature
| S-EPMC6605008 | biostudies-literature
| S-EPMC4392557 | biostudies-literature
| S-EPMC6303156 | biostudies-literature
| S-EPMC9134390 | biostudies-literature
| S-EPMC6149678 | biostudies-literature
| S-EPMC8616435 | biostudies-literature