Unknown

Dataset Information

0

Anti-Cancer and Anti-Inflammatory Activities of Three New Chromone Derivatives from the Marine-Derived Penicillium citrinum.


ABSTRACT: Three new and uncommon chromone analogs, epiremisporine F (1), epiremisporine G (2), and epiremisporine H (3), were isolated from marine-origin Penicillium citrinum. Among the isolated compounds, compounds 2-3 remarkably suppressed fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 31.68 ± 2.53, and 33.52 ± 0.42 μM, respectively. Compound 3 exhibited cytotoxic activities against human colon carcinoma (HT-29) and non-small lung cancer cell (A549) with IC50 values of 21.17 ± 4.89 and 31.43 ± 3.01 μM, respectively, and Western blot assay confirmed that compound 3 obviously induced apoptosis of HT-29 cells, via Bcl-2, Bax, and caspase 3 signaling cascades.

SUBMITTER: Chu YC 

PROVIDER: S-EPMC8398383 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7827422 | biostudies-literature
| S-EPMC4728511 | biostudies-literature
| S-EPMC8434415 | biostudies-literature
| S-EPMC6357177 | biostudies-literature
| S-EPMC6669556 | biostudies-literature
| S-EPMC5082325 | biostudies-literature
| S-EPMC8676454 | biostudies-literature
| S-EPMC6117697 | biostudies-literature
| S-EPMC7230553 | biostudies-literature
| S-EPMC6270126 | biostudies-literature