Recent Advances in BTK Inhibitors for the Treatment of Inflammatory and Autoimmune Diseases.

ABSTRACT: Bruton's tyrosine kinase (BTK) plays a crucial role in B-cell receptor and Fc receptor signaling pathways. BTK is also involved in the regulation of Toll-like receptors and chemokine receptors. Given the central role of BTK in immunity, BTK inhibition represents a promising therapeutic approach for the treatment of inflammatory and autoimmune diseases. Great efforts have been made in developing BTK inhibitors for potential clinical applications in inflammatory and autoimmune diseases. This review covers the recent development of BTK inhibitors at preclinical and clinical stages in treating these diseases. Individual examples of three types of inhibitors, namely covalent irreversible inhibitors, covalent reversible inhibitors, and non-covalent reversible inhibitors, are discussed with a foc

SUBMITTER: Zhang D 

PROVIDER: S-EPMC8399599 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature