Ontology highlight
ABSTRACT:
SUBMITTER: Dart CR
PROVIDER: S-EPMC8399604 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Dart Chiara R CR Mukherjee Nabanita N Amato Carol M CM Goulding Anabel A MacBeth Morgan M Van Gulick Robert R Couts Kasey L KL Lambert James R JR Norris David A DA Robinson William A WA Shellman Yiqun G YG
Pharmaceuticals (Basel, Switzerland) 20210730 8
Although treatment options for melanoma patients have expanded in recent years with the approval of immunotherapy and targeted therapy, there is still an unmet need for new treatment options for patients that are ineligible for, or resistant to these therapies. BH3 mimetics, drugs that mimic the activity of pro-apoptotic BCL2 family proteins, have recently achieved remarkable success in the clinical setting. The combination of BH3 mimetic ABT-199 (venetoclax) plus azacitidine has shown substanti ...[more]