Ontology highlight
ABSTRACT:
SUBMITTER: Zermeno-Macias MLA
PROVIDER: S-EPMC8401487 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Zermeño-Macías María de Los Ángeles MLÁ González-Chávez Marco Martín MM Méndez Francisco F Richaud Arlette A González-Chávez Rodolfo R Ojeda-Fuentes Luis Enrique LE Niño-Moreno Perla Del Carmen PDC Martínez Roberto R
Molecules (Basel, Switzerland) 20210821 16
The assertion made by Wu et al. that aromaticity may have considerable implications for molecular design motivated us to use nucleus-independent chemical shifts (NICS) as an aromaticity criterion to evaluate the antifungal activity of two series of indol-4-ones. A linear regression analysis of NICS and antifungal activity showed that both tested variables were significantly related (<i>p</i> < 0.05); when aromaticity increased, the antifungal activity decreased for series I and increased for ser ...[more]