Restricted Water Intake Adversely Affects Rat Vocal Fold Biology.

ABSTRACT:

Objectives

A holistic understanding of the many ways that systemic dehydration affects vocal fold biology is still evolving. There are also myriad physiologically relevant methodologies to induce systemic dehydration. To untangle the effects of systemic dehydration on vocal fold biology, we need to utilize realistic, clinically translatable paradigms of systemic dehydration in lab animals. Restricted access to water accommodates clinical translation. We investigated whether systemic dehydration via reduced water intake would negatively affect vocal fold biology.

Study design

Prospective, in vivo study design.

Methods

Male Sprague Dawley rats (N = 13) were provided 4 mL/100 g of water/day for 5 days, whereas male control rats (N = 8) were given ad lib access to water.

SUBMITTER: Duan C 

PROVIDER: S-EPMC8404141 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature