Unknown

Dataset Information

0

GABA and glutamate in the preterm neonatal brain: In-vivo measurement by magnetic resonance spectroscopy.


ABSTRACT: Cognitive and behavioral disabilities in preterm infants, even without obvious brain injury on conventional neuroimaging, underscores a critical need to identify the subtle underlying microstructural and biochemical derangements. The gamma-aminobutyric acid (GABA) and glutamatergic neurotransmitter systems undergo rapid maturation during the crucial late gestation and early postnatal life, and are at-risk of disruption after preterm birth. Animal and human autopsy studies provide the bulk of current understanding since non-invasive specialized proton magnetic resonance spectroscopy (1H-MRS) to measure GABA and glutamate are not routinely available for this vulnerable population due to logistical and technical challenges. We review the specialized 1H-MRS techniques including MEscher-GArwood Point Resolved Spectroscopy (MEGA-PRESS), special challenges and considerations needed for interpretation of acquired data from the developing brain of preterm infants. We summarize the limited in-vivo preterm data, highlight the gaps in knowledge, and discuss future directions for optimal integration of available in-vivo approaches to understand the influence of GABA and glutamate on neurodevelopmental outcomes after preterm birth.

SUBMITTER: Basu SK 

PROVIDER: S-EPMC8404144 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8204265 | biostudies-literature
| S-EPMC7507577 | biostudies-literature
| S-EPMC3071441 | biostudies-literature
| S-EPMC7522573 | biostudies-literature
| S-EPMC5970172 | biostudies-literature
| S-EPMC9484292 | biostudies-literature
2023-04-25 | GSE225302 | GEO
| S-EPMC7645149 | biostudies-literature
| S-EPMC5225214 | biostudies-literature
| S-EPMC5497851 | biostudies-other